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Review
11.
Mesenchymal stem cells and
it's characterization -
M. D. Pratheesh, Pawan K Dubey, Amar Nath, Nitin E
Gade, Rajesh Kumar, G. Taru Sharma
Vet World. 2011; 4(12): 571-574
doi: 10.5455/vetworld.2011.571-574
Abstract
Although acceptable for cell based therapeutic
applications, a rigorous understanding of the
Mesenchymal Stem Cells (MSC) requires a better
definition of what an MSC is. Inspite of the fact
that no unique markers are known for MSCs, many
attempts have been made to develop a cell-surface
antigen profile for the better purification and
identification of MSCs, particularly important is
whether MSCs isolated from different tissues are
identifiable by the same immunophenotype. While
the precise identity of MSCs remains a challenge,
further understanding of their biological
properties will be greatly advanced by analyzing
the mechanisms that govern their differentiation
potential. The ability of MSCs to differentiate
into a variety of connective tissue cell types has
rendered them an ideal candidate cell source for
clinical tissue regeneration strategies. This
review focuses specifically in the context of
these advances in characterization of adult stem
cells via selection of unique cell surface markers
and regulation of lineage- specific
differentiation of mesenchymal stem cells.
Keywords: Mesenchymal Stem Cells, Bone Marrow,
Cellular Therapy, Immunologic Property.
